Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma: a retrospective national study from TMRG and GINECO network.

ABSTRACT:

Background

Uterine clear cell carcinomas (CCC) represent less than 5% of uterine cancers. Their biological characteristics and clinical management remain uncertain. A multicenter study to explore both clinical and molecular features of these rare tumors was conducted.

Methods

This multicenter retrospective national study was performed within the French TMRG (Rare Gynecologic Malignant Tumors) network. Clinical data and, when available, FFPE blocks were collected. Clinical features, treatments, and outcome (progression-free survival (PFS) and overall survival (OS)) were analyzed and correlated to the protein (tissue micro-array), RNA (Nanostring nCounter^® technology), and DNA (array-Comparative Genomic hybridization and target-next generation sequencing) levels usi

SUBMITTER: Nigon E 

PROVIDER: S-EPMC10288685 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature