Differential response to donepezil in MRI subtypes of mild cognitive impairment.

ABSTRACT:

Background

Donepezil is an approved therapy for the treatment of Alzheimer's disease (AD). Results across clinical trials have been inconsistent, which may be explained by design-methodological issues, the pathophysiological heterogeneity of AD, and diversity of included study participants. We investigated whether response to donepezil differs in mild cognitive impaired (MCI) individuals demonstrating different magnetic resonance imaging (MRI) subtypes.

Methods

From the Hippocampus Study double-blind, randomized clinical trial, we included 173 MCI individuals (donepezil = 83; placebo = 90) with structural MRI data, at baseline and at clinical follow-up assessments (6-12-month). Efficacy outcomes were the annualized percentage change (APC) in hippocampal, ventricular, and tot

SUBMITTER: Diaz-Galvan P 

PROVIDER: S-EPMC10288762 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature