Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans.

ABSTRACT:

Background

Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. Despite data linking chronic environmental, physiological, and psychosocial stressors with accelerated aging, how stress contributes to immunosenesence is not well characterized.

Objective

To help delineate the contribution of cumulative physiological stress on immunosensence we assessed relationships between a composite measurement of cumulative physiological stress, reflecting the functioning of the hypothalamic-pituitary-adrenal axis, sympathetic nervous system, cardiovascular system, and metabolic processes, and lymphocyte changes typically affiliated with aging in a cohort of healthy volunteers ranging from 18 to 66 y.

Results

Physio

SUBMITTER: Snodgrass RG 

PROVIDER: S-EPMC10288764 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature