Genetic deletion of hepatic NCOR1 protects from atherosclerosis by promoting alternative bile acid-metabolism and sterol excretion.

ABSTRACT:

Background

The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression in immunometabolic conditions by connecting chromatin-modifying enzymes, coregulators and transcription factors. NCOR1 has been shown to be involved in cardiometabolic diseases. Recently, we demonstrated that the deletion of macrophage NCOR1 aggravates atherosclerosis by promoting CD36-triggered foam cell formation via PPARG derepression.

Purpose

Since NCOR1 modulates the function of several key regulators involved in hepatic lipid and bile acid metabolism, we hypothesized that its deletion in hepatocytes alters lipid metabolism and atherogenesis.

Methods

To test this hypothesis, we generated hepatocyte-specific Ncor1 knockout mice on a Ldlr-/- background

SUBMITTER: Geiger M 

PROVIDER: S-EPMC10288794 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature