Divergent mechanical properties of older human male femora reveal unique combinations of morphological and compositional traits contributing to low strength.

ABSTRACT: Bone strength is generally thought to decline with aging and prior work has compared traits between younger and older cohorts to identify the structural and compositional changes that contribute to fracture risk with age. However, for men, the majority of individuals do not fracture a bone in their lifetime. While fracture occurrence is multifactorial, the absence of fracture in the majority of males suggests that some individuals maintain bone strength or do not lose enough strength to fracture, whereas others do lose strength with aging. Consequently, not all structural and material changes observed with age may lead to strength-decline. We propose that consideration of different subgroups of older individuals will provide a more precise understanding of which structural and material cha

SUBMITTER: Bolger MW 

PROVIDER: S-EPMC10288834 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature