CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation.

ABSTRACT:

Background

Infants born extremely premature are at increased risk for health complications later in life for which neonatal inflammation may be a contributing biological driver. Placental CpG methylation provides mechanistic information regarding the relationship between prenatal epigenetic programming, prematurity, neonatal inflammation, and later-in-life health.

Methods

We contrasted CpG methylation in the placenta and neonatal blood spots in relation to neonatal inflammation in the Extremely Low Gestational Age Newborn (ELGAN) cohort. Neonatal inflammation status was based on the expression of six inflammation-related proteins, assessed as (1) day-one inflammation (DOI) or (2) intermittent or sustained systemic inflammation (ISSI, inflammation on ≥2 days in the first 2 po

SUBMITTER: Eaves LA 

PROVIDER: S-EPMC10289042 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature