Differences in tissue-associated bacteria between metastatic and non-metastatic colorectal cancer.

ABSTRACT:

Background and aims

Accumulated evidence indicates that the intestinal microbiota plays crucial roles in the initiation and progression of colorectal cancer (CRC). However, the effects of the tissue-associated microbiota on CRC metastasis are poorly defined. The aim of this study was to explore the differences in bacteria between metastatic and non-metastatic CRC tissues and identify potential bacterial species that associate with CRC metastasis.

Methods

16S rDNA amplicon high-throughput sequencing was used to test the intestinal tissue-associated microbiota in patients with metastatic CRC (n = 48) and non-metastatic CRC (n = 44). The microbial diversity and differential species were analysed by standard microbiological methods, and then the differential bacter

SUBMITTER: Zhou P 

PROVIDER: S-EPMC10289161 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature