Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis.

ABSTRACT:

Background and aims

Acute severe steroid-refractory ulcerative colitis remains a medically challenging condition with frequent need of surgery. It can be treated with the calcineurin inhibitor cyclosporine A with the need for therapeutic drug monitoring and significant toxicity. Recently, a novel calcineurin inhibitor, voclosporin, has been approved for the treatment of lupus nephritis with no need for therapeutic drug monitoring and an improved long-term safety profile. However, the therapeutic effect of voclosporin in acute severe steroid-refractory ulcerative colitis is still uncertain. We aimed to assess the therapeutic potential of voclosporin to ameliorate inflammation in an experimental model of colitis.

Methods

We used the dextran sodium sulfate-induced model of coli

SUBMITTER: Lindemann A 

PROVIDER: S-EPMC10289195 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature