Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.

ABSTRACT:

Background and aim

Gastric cancer (GC) is a prevalent malignancy worldwide. Pulsatilla decoction (PD), a traditional Chinese medicine formula, can treat inflammatory bowel disease and cancers. In this study, we explored the bioactive components, potential targets, and molecular mechanisms of PD in the treatment of GC.

Methods

We conducted a thorough search of online databases to gather gene data, active components, and potential target genes associated with the development of GC. Subsequently, we conducted bioinformatics analysis utilizing protein-protein interaction (PPI), network construction, and Kyoto Encyclopedia of Genes and Genomes (KEGG) to identify potential anticancer components and therapeutic targets of PD. Finally, the efficacy of PD in treating GC was fu

SUBMITTER: Huang S 

PROVIDER: S-EPMC10289198 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature