Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease.

ABSTRACT: Neovascular eye diseases include conditions such as retinopathy of prematurity, proliferative diabetic retinopathy, and neovascular age-related macular degeneration. Together, they are a major cause of vision loss and blindness worldwide. The current therapeutic mainstay for these diseases is intravitreal injections of biologics targeting vascular endothelial growth factor (VEGF) signaling. Lack of universal response to these anti-VEGF agents coupled with the challenging delivery method underscore a need for new therapeutic targets and agents. In particular, proteins that mediate both inflammatory and proangiogenic signaling are appealing targets for new therapeutic development. Here, we review agents currently in clinical trials and highlight some promising targets in preclinical and earl

SUBMITTER: Muniyandi A 

PROVIDER: S-EPMC10289243 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature