Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.

ABSTRACT:

Background

The continuous evolution of SARS-CoV-2 has underscored the development of broad-spectrum prophylaxis. Antivirals targeting the membrane fusion process represent promising paradigms. Kaempferol (Kae), an ubiquitous plant flavonol, has been shown efficacy against various enveloped viruses. However, its potential in anti-SARS-CoV-2 invasion remains obscure.

Purpose

To evaluate capabilities and mechanisms of Kae in preventing SARS-CoV-2 invasion.

Methods

To avoid interference of viral replication, virus-like particles (VLPs) constructed with luciferase reporter were applied. To investigate the antiviral potency of Kae, human induced pluripotent stem cells (hiPSC)-derived alveolar epithelial cells type II (AECII) and human ACE2 (hACE2) transgenic mice were utili

SUBMITTER: Gao J 

PROVIDER: S-EPMC10289257 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature