Application of tumor pH/hypoxia-responsive nanoparticles for combined photodynamic therapy and hypoxia-activated chemotherapy.

ABSTRACT: Introduction: Cancer selectivity, including targeted internalization and accelerated drug release in tumor cells, remains a major challenge for designing novel stimuli-responsive nanocarriers to promote therapeutic efficacy. The hypoxic microenvironment created by photodynamic therapy (PDT) is believed to play a critical role in chemoresistance. Methods: We construct dual-responsive carriers (^DANP_CT) that encapsulate the photosensitizer chlorin e6 (Ce6) and hypoxia-activated prodrug tirapazamine (TPZ) to enable efficient PDT and PDT-boosted hypoxia-activated chemotherapy. Results and discussion: Due to TAT masking, ^DANP_CT prolonged payload circulation in the bloodstream, and selective tumor cell uptake occurred via acidity-tr

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10289258 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature