Photoreceptor-Specific Temporal Contrast Sensitivities in RP1L1-Associated Occult Macular Dystrophy.

ABSTRACT:

Purpose

The purpose of this study was to compare L-, M-, S-cone-, and rod-driven temporal contrast sensitivities (tCS) in patients with RP1L1-associated autosomal-dominant occult macular dystrophy (OMD), and to investigate how photoreceptor degeneration determines which post-receptoral channels dominate perception.

Methods

Photoreceptor isolating stimuli were created with the silent substitution technique. Photoreceptor-selective tCS deviations (D L-cone/M-cone/S-cone/Rod) were obtained as a function of temporal frequency with identical retinal adaptation, by subtracting tCS from age-corrected normal values. A linear-mixed effects model was used for analysis.

Results

Eleven genetically confirmed patients were included (7 women, 5 men; age = 52.27 ± 14.44 years). Overa

SUBMITTER: Huchzermeyer C 

PROVIDER: S-EPMC10289274 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature