Kratom use disorder and unfolded protein response: Evaluating their relationship in a case control study.

ABSTRACT:

Background and aims

Kratom (Mitragyna speciosa Korth.) is widely use worldwide despite its addictive potential. Although psychostimulant use has been linked to occurrence of endoplasmic reticulum (ER) stress, data is lacking on how regular kratom use affects ER stress. This case-control study first determined differences in ER stress sensor protein expression (BiP, sXBP1, ATF4, CHOP, JNK, and p-JNK) between regular kratom users and healthy controls. Second, it evaluated the association between kratom use characteristics, targeted ER stress sensor protein expression, and "kratom use disorder" diagnosed with Diagnostic and Statistical Manual for Mental Disorders 5th Edition (DSM-5) among regular kratom users.

Methods

In total, 60 regular kratom users and 50 healthy control-gro

SUBMITTER: Yang B 

PROVIDER: S-EPMC10289391 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature