Neuromodulatory effects and reproducibility of the most widely used repetitive transcranial magnetic stimulation protocols.

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (rTMS) is widely used in both research and clinical settings to modulate human brain function and behavior through the engagement of the mechanisms of plasticity. Based upon experiments using single-pulse TMS as a probe, the physiologic mechanism of these effects is often assumed to be via changes in cortical excitability, with 10 Hz rTMS increasing and 1 Hz rTMS decreasing the excitability of the stimulated region. However, the reliability and reproducibility of these rTMS protocols on cortical excitability across and within individual subjects, particularly in comparison to robust sham stimulation, have not been systematically examined.

Objectives

In a cohort of 28 subjects (39 ± 16 years), we report the first compreh

SUBMITTER: Magnuson J 

PROVIDER: S-EPMC10289434 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature