Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate.

ABSTRACT:

Introduction

Based on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic mechanism of ECT. This model implies that a temporary disturbance of neuronal networks (disruption) is followed by a trophic effect (potentiation), which enables the rewiring of neuronal circuits to a more euthymic functioning brain. We hypothesized that disruption of neuronal networks could trigger biochemical alterations leading to a temporary decrease in N-acetylaspartate (tNAA, considered a marker of neuronal integrity), while choline (a membrane component), myo-Inositol (mI, astroglia marker), and glutamate/glutamine (Glx, excitatory neurotransmi

SUBMITTER: Erchinger VJ 

PROVIDER: S-EPMC10289547 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature