An information theoretic method to resolve millisecond-scale spike timing precision in a comprehensive motor program.

ABSTRACT: Sensory inputs in nervous systems are often encoded at the millisecond scale in a precise spike timing code. There is now growing evidence in behaviors ranging from slow breathing to rapid flight for the prevalence of precise timing encoding in motor systems. Despite this, we largely do not know at what scale timing matters in these circuits due to the difficulty of recording a complete set of spike-resolved motor signals and assessing spike timing precision for encoding continuous motor signals. We also do not know if the precision scale varies depending on the functional role of different motor units. We introduce a method to estimate spike timing precision in motor circuits using continuous MI estimation at increasing levels of added uniform noise. This method can assess spike timing pr

SUBMITTER: Ortega J 

PROVIDER: S-EPMC10289674 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature