Gut microbiota composition and function in pregnancy as determinants of prediabetes at two-year postpartum.

ABSTRACT:

Aims

Deep metagenomics offers an advanced tool for examining the relationship between gut microbiota composition and function and the onset of disease; in this case, does the composition and function of gut microbiota during pregnancy differ in women who develop prediabetes and those who do not at two-year postpartum, and whether the gut microbiota composition associates with glycemic traits.

Methods

In total, 439 women were recruited in early pregnancy. Gut microbiota was assessed by metagenomics analysis in early (13.9 ± 2.0 gestational weeks) and late pregnancy (35.1 ± 1.0 gestational weeks). Prediabetes was determined using American Diabetes Association criteria as fasting plasma glucose 5.6-6.9 mmol/l analyzed by an enzymatic hexokinase method. Of the women, 39 (22.1%)

SUBMITTER: Houttu N 

PROVIDER: S-EPMC10289902 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature