Comparison of gas chromatographic techniques for the analysis of iodinated derivatives of aromatic amines.

ABSTRACT: Some aromatic amines (AA) have been classified as carcinogens to humans. After entering the body, mainly through tobacco smoke, they can be detected in urine. Thus, their trace analysis as biomarkers in biofluids is of high relevance and can be achieved with gas chromatography (GC-MS), usually after derivatization. This study compares three gas chromatographic methods for the analysis of ten iodinated derivatives of AA: GC-MS in single-ion monitoring (SIM) mode with (1) electron ionization (GC-EI-MS) and (2) negative chemical ionization (GC-NCI-MS), and (3) GC-EI-MS/MS in multiple reaction monitoring (MRM) mode using electron ionization. All methods and most analytes showed good coefficients of determination (R² > 0.99) for broad linear ranges covering three to five orders of ma

SUBMITTER: Lorenzo-Parodi N 

PROVIDER: S-EPMC10289911 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature