Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes.

ABSTRACT:

Aims

The purpose of this review is to explore the interconnected pathways of the microbiota-gut-brain axis (MGBA), focusing on the roles of the vagus nerve and glucagon like peptide-1 in appetite control, and in the development of obesity and diabetes.

Methods

Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders whose prevalence has significantly increased in recent decades and is expected to increase every year, to pandemic proportions. These two pathologies often coexist and have substantial public health implications. The term "diabesity" defines the pathophysiological connection between overweight and T2DM. The gut microbiota affects many aspects of the host. Beyond the regulation of intestinal functions and the activation of immune responses, the gut micr

SUBMITTER: Longo S 

PROVIDER: S-EPMC10289935 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature