Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.

ABSTRACT: Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention efforts. We investigated whether polygenic risk for bipolar disorder is associated with developmental outcomes during early to middle childhood in the general population, and if associations differ between boys and girls. Our sample consisted of 28 001 children from the Norwegian Mother, Father and Child Cohort study, a prospective pregnancy cohort with available genotype and developmental data. Mothers reported on a range of developmental outcomes in their children at 6 and 18 months, 3, 5 and 8 years. Polygenic risk scores reflecting common variant liability to bipolar disor

SUBMITTER: Askeland RB 

PROVIDER: S-EPMC10290060 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature