Resting heart rate and antisocial behaviour: a Mendelian randomisation study.

ABSTRACT: Observational studies frequently report phenotypic associations between low resting heart rate (RHR) and higher levels of antisocial behaviour (ASB), although it remains unclear whether this relationship reflects causality. To triangulate evidence, we conducted two-sample univariable Mendelian randomisation (MR), multivariable MR and linkage disequilibrium score regression (LDSC) analyses. Genetic data were accessed from published genome-wide association studies (GWAS) for RHR (n = 458,835) and ASB (n = 85,359) for the univariable analyses, along with a third GWAS for heart rate variability (HRV; n = 53,174) for all other analyses. Genome-wide significant (p < 5 × 10^-8) single-nucleotide polymorphisms associated with RHR (n = 278) were selected as instrumental variables and the

SUBMITTER: Karwatowska L 

PROVIDER: S-EPMC10290077 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature