Using macular velocity measurements to relate parameters of bone conduction to vestibular compound action potential responses.

ABSTRACT: To examine mechanisms responsible for vestibular afferent sensitivity to transient bone conducted vibration, we performed simultaneous measurements of stimulus-evoked vestibular compound action potentials (vCAPs), utricular macula velocity, and vestibular microphonics (VMs) in anaesthetized guinea pigs. Results provide new insights into the kinematic variables of transient motion responsible for triggering mammalian vCAPs, revealing synchronized vestibular afferent responses are not universally sensitive to linear jerk as previously thought. For short duration stimuli (< 1 ms), the vCAP increases magnitude in close proportion to macular velocity and temporal bone (linear) acceleration, rather than other kinematic elements. For longer duration stimuli, the vCAP magnitude switches from tempo

SUBMITTER: Pastras CJ 

PROVIDER: S-EPMC10290084 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature