A newly identified small tRNA fragment reveals the regulation of different wool types and oxidative stress in lambs.

ABSTRACT: Novel small RNAs derived from tRNAs are continuously identified, however, their biological functions are rarely reported. Here, we accidentally found the reads peak at 32nt during statistical analysis on the miRNA-seq data of lamb skin tissue, and found that it was related to the wool type of lambs. This 32nt peak was composed of small tRNA fragments. The main component sequence of this peak was a novel small tRNA derived from Glycyl tRNA (tRNA^Gly), the expression level of tRNA^Gly-derived tRNA fragments (tRF^Gly) was 5.77 folds higher in the coarse wool lambs than that in the fine wool lambs. However, in contrast, the expression of tRNA^Gly in the skin of fine wool lambs is 6.28 folds more than that in coarse wool lambs. tRNA^Gly promoted

SUBMITTER: Wang J 

PROVIDER: S-EPMC10290153 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature