DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer.

ABSTRACT:

Motivation

Large-scale genetic and pharmacologic dependency maps are generated to reveal genetic vulnerabilities and drug sensitivities of cancer. However, user-friendly software is needed to systematically link such maps.

Results

Here, we present DepLink, a web server to identify genetic and pharmacologic perturbations that induce similar effects on cell viability or molecular changes. DepLink integrates heterogeneous datasets of genome-wide CRISPR loss-of-function screens, high-throughput pharmacologic screens and gene expression signatures of perturbations. The datasets are systematically connected by four complementary modules tailored for different query scenarios. It allows users to search for potential inhibitors that target a gene (Module 1) or multiple genes (Module

SUBMITTER: Nayak T 

PROVIDER: S-EPMC10290235 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature