Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes.

ABSTRACT:

Background

Ivermectin (22,23-dihydroavermectin B_1a: H₂B_1a) is an endectocide used to treat worm infections and ectoparasites including lice and scabies mites. Furthermore, survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated with ivermectin. Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has also been reported, in which the survival of mosquitoes remains reduced even after ivermectin is no longer detectable in blood meals. In the present study, existing material from human clinical trials was analysed to understand the pharmacokinetics of

SUBMITTER: Kern C 

PROVIDER: S-EPMC10290335 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature