Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure.

ABSTRACT:

Background

It is crucial to maintain the intracranial pressure (ICP) within the physiological range to ensure proper brain function. The ICP may fluctuate during the light-dark phase cycle, complicating diagnosis and treatment choice in patients with pressure-related disorders. Such ICP fluctuations may originate in circadian or sleep-wake cycle-mediated modulation of cerebrospinal fluid (CSF) flow dynamics, which in addition could support diurnal regulation of brain waste clearance.

Methods

ICP was monitored continuously in patients who underwent placement of an external ventricular drain (EVD) and by telemetric monitoring in experimental rats. CSF was collected via the EVD in patients and the rodent CSF secretion rate determined by in vivo experimentation. Rodent choroid p

SUBMITTER: Steffensen AB 

PROVIDER: S-EPMC10290349 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature