Interferon-induced transmembrane protein 3 in hepatocellular carcinoma patients.

ABSTRACT:

Objective

The study aimed to investigate the over expression of IFITM3 in hepatocellular carcinoma Egyptian patients.

Background

Hepatocellular carcinoma (HCC) continues to be a serious disease burden. Interferon Induced Transmembrane protein 3 (IFITM3) is a protein that encoded in humans by the IFITM3 gene. It plays a critical role in the immune system's defense, responsible for a large portion of the antiviral activity. In this study, we showed that IFITM3 rs 12252-CC was over expressed in HCC patients compared to control group with HCV infection.

Method

DNA sequencing was applied for detection of IFITM3 rs 12252-CC and IFITM3 protein level was measured by ELISA to 50 patients with HCC with cirrhosis and 50 with Hepatitis C virus infection.

Results

The obtain

SUBMITTER: Bondok RM 

PROVIDER: S-EPMC10290370 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature