Circulating prekallikrein levels are correlated with lipid levels in the chinese population: a cross-sectional study.

ABSTRACT:

Background

Recent evidence has revealed that circulating coagulation factor prekallikrein (PK), an important part of the kallikrein-kinin system, regulates cholesterol metabolism, but the association between serum PK and lipid levels is unclear.

Methods

This cross-sectional study included 256 subjects (aged from 1 month to 90 years) who underwent physical examinations at the First People's Hospital of Huaihua, China. After overnight fasting, serum was collected for PK and lipid testing. Spearman correlation analysis and multivariable logistic regression analysis were used to analyze the association of PK level with lipid levels and the likelihood risk of hyperlipidemia. The possible threshold value of PK was calculated according to the receiver operating characteristic (ROC)

SUBMITTER: Shu Y 

PROVIDER: S-EPMC10290373 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature