Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing.

ABSTRACT:

Background

Currently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent wheezing. We investigated iron homeostasis in the airways of preschoolers with recurrent wheezing and assessed whether iron homeostasis-related indices may reliably predict persistent wheezing.

Methods

Iron levels and mRNA expression levels of iron homeostasis molecules were examined in bronchoalveolar lavage samples from 89 preschoolers with recurrent wheezing and 56 controls, with a 12-month follow-up conducted. Risk factors for persistent wheezing were identified using least absolute shrinkage and selection operator and multivariate logistic regression. The addition of predictive values of iron indices to the modified Asthma P

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10290382 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature