Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank.

ABSTRACT: Psychiatric disorders are complex clinical conditions with large heterogeneity and overlap in symptoms, genetic liability and brain imaging abnormalities. Building on a dimensional conceptualization of mental health, previous studies have reported genetic overlap between psychiatric disorders and population-level mental health, and between psychiatric disorders and brain functional connectivity. Here, in 30,701 participants aged 45-82 from the UK Biobank we map the genetic associations between self-reported mental health and resting-state fMRI-based measures of brain network function. Multivariate Omnibus Statistical Test revealed 10 genetic loci associated with population-level mental symptoms. Next, conjunctional FDR identified 23 shared genetic variants between these symptom profiles an

SUBMITTER: Roelfs D 

PROVIDER: S-EPMC10290393 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature