Local anesthetics systemic toxicity in children: analysis of the French pharmacovigilance database.

ABSTRACT:

Purpose

To characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening outcomes.

Methods

Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the following criteria: LA as suspected drug, age < 18 years, adverse drug reactions related to nervous system, cardiac, respiratory, psychiatric or general disorders. Multivariate logistic regression analysis was performed to identify factors leading to life-threatening reaction (i.e. continuous seizures or cardiorespiratory arrest).

Results

Among 512 cases retrieved, 64 LAST cases were included (neonates 11%, infants 30%, children 36%, adolescents 23%) mainly involvin

SUBMITTER: Schweitzer-Chaput A 

PROVIDER: S-EPMC10290397 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature