Advances toward precision medicine for bipolar disorder: mechanisms & molecules.

ABSTRACT: Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%, the effective treatment, and prevention of bipolar disorder represents an area of significant unmet medical need. While more than half a century has passed since the introduction of lithium into widespread use at the birth of modern psychopharmacology, that medication remains a mainstay for the acute treatment and prevention of recurrent mania/hypomania and depression that characterize bipolar disorder. However, the continued limited understanding of how lithium modulates affective behavior and lack of validated cellular and animal models have resulted in obstacles to discovering more effective mood stabilizers with fewer adverse side effects. In particular, while there has been progress in deve

SUBMITTER: Haggarty SJ 

PROVIDER: S-EPMC10290523 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature