Ontology highlight
ABSTRACT:
SUBMITTER: Pan R
PROVIDER: S-EPMC10290635 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Pan Rulu R Dai Juji J Liang Weicheng W Wang Hongxiao H Ye Lin L Ye Siqi S Lin Ziqi Z Huang Shishun S Xiong Yan Y Zhang Li L Lu Liting L Wang Ouchen O Shen Xian X Liao Wanqin W Lu Xincheng X
Cell death & disease 20230624 6
Phosphodiesterase 4D interacting protein (PDE4DIP) is a centrosome/Golgi protein associated with cyclic nucleotide phosphodiesterases. PDE4DIP is commonly mutated in human cancers, and its alteration in mice leads to a predisposition to intestinal cancer. However, the biological function of PDE4DIP in human cancer remains obscure. Here, we report for the first time the oncogenic role of PDE4DIP in colorectal cancer (CRC) growth and adaptive MEK inhibitor (MEKi) resistance. We show that the expre ...[more]