Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation.

ABSTRACT: Tissue-dwelling helminths affect billions of people around the world. They are potent manipulators of the host immune system, prominently by promoting regulatory T cells (Tregs) and are generally associated with a modified host gut microbiome. However, the role of the gut microbiota in the immunomodulatory processes for these non-intestinal parasites is still unclear. In the present study, we used an extra-intestinal cestode helminth model-larval Echinococcus multilocularis to explore the tripartite partnership (host-helminth-bacteria) in the context of regulating colonic Tregs in Balb/c mice. We showed that larval E. multilocularis infection in the peritoneal cavity attenuated colitis in Balb/c mice and induced a significant expansion of colonic Foxp3⁺ Treg populations. Fecal m

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10290639 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature