Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post-operative delirium.

ABSTRACT:

Purpose

Delirium presents a significant healthcare burden. It complicates post-operative care in up to 50% of cardiac surgical patients with worse outcomes, longer hospital stays and higher cost of care. Moreover, the nature of delirium following cardiac surgery with cardiopulmonary bypass (CPB) remains unclear, the underlying pathobiology is poorly understood, status quo diagnostic methods are subjective, and diagnostic biomarkers are currently lacking.

Objective

To identify diagnostic biomarkers of delirium and for insights into possible neuronal pathomechanisms.

Experimental design

Comparative proteomic analyses were performed on plasma samples from a nested matched cohort of patients who underwent cardiac surgery. Validation by targeted proteomics was performed in

SUBMITTER: Wiredu K 

PROVIDER: S-EPMC10290728 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature