Comparison of the clinical value of MRI and plasma markers for cognitive impairment in patients aged ≥75 years: a retrospective study.

ABSTRACT:

Background

Dementia has become the main cause of disability in older adults aged ≥75 years. Cerebral small vessel disease (CSVD) is involved in cognitive impairment (CI) and dementia and is a cause of vascular CI (VCI), which is manageable and its onset and progression can be delayed. Simple and effective markers will be beneficial to the early detection and intervention of CI. The aim of this study is to investigate the clinical application value of plasma amyloid β1-42 (Aβ42), phosphorylated tau 181 (p-tau181) and conventional structural magnetic resonance imaging (MRI) parameters for cognitive impairment (CI) in patients aged ≥75 years.

Methods

We retrospectively selected patients who visited the Affiliated Hospital of Xuzhou Medical University and were clinically diagnos

SUBMITTER: Wang W 

PROVIDER: S-EPMC10290829 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature