Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots.

ABSTRACT: Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipoge

SUBMITTER: Palani NP 

PROVIDER: S-EPMC10290958 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature