Variants in <i>JAZF1</i> are associated with asthma, type 2 diabetes, and height in the United Kingdom biobank population.

ABSTRACT: Background: Asthma, type 2 diabetes (T2D), and anthropometric measures are correlated complex traits that all have a major genetic component. Objective: To investigate the overlap in genetic variants associated with these complex traits. Methods: Using United Kingdom Biobank data, we performed univariate association analysis, fine-mapping, and mediation analysis to identify and dissect shared genomic regions associated with asthma, T2D, height, weight, body mass index (BMI), and waist circumference (WC). Results: We found several genome-wide significant variants in and around the JAZF1 gene that are associated with asthma, T2D, or height with two of these variants shared by the three phenotypes. We also observed an association in this region with WC when

SUBMITTER: DeWan AT 

PROVIDER: S-EPMC10291233 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature