Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO₂F₂).

ABSTRACT: A SO₂F₂-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration selectivity. This new method features wide substrate scope, mild conditions, and direct N-O activation.

SUBMITTER: Chen XL 

PROVIDER: S-EPMC10291241 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature