Ontology highlight
ABSTRACT:
SUBMITTER: Carim SC
PROVIDER: S-EPMC10291328 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Carim Sabrya C SC Hickson Gilles R X GRX
iScience 20230519 6
Animal cell cytokinesis requires activation of the GTPase RhoA (Rho1 in <i>Drosophila</i>), which assembles an F-actin- and myosin II-dependent contractile ring (CR) at the equatorial plasma membrane. CR closure is poorly understood, but involves the multidomain scaffold protein, Anillin. Anillin binds many CR components including F-actin and myosin II (collectively actomyosin), RhoA and the septins. Anillin recruits septins to the CR but the mechanism is unclear. Live imaging of <i>Drosophila</ ...[more]