Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice.

ABSTRACT: Despite progress in reperfusion therapy, functional recovery remains suboptimal in many stroke patients, with oxidative stress, inflammation, dysbiosis, and secondary neurodegeneration constituting the major hurdles to recovery. The essential trace element selenium is emerging as a promising therapeutic agent for stroke. However, although several rodent studies have shown that selenium can protect against cell loss following cerebral ischemia, no study has yet examined whether selenium can enhance long-term functional recovery. Moreover, published studies have typically reported a single mechanism of action underlying selenium-mediated stroke recovery. However, we propose that selenium is more likely to have multifaceted actions. Here, we show that selenomethionine confers a potent neuropr

SUBMITTER: Zhuo Z 

PROVIDER: S-EPMC10291447 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature