Ontology highlight
ABSTRACT:
SUBMITTER: Cai L
PROVIDER: S-EPMC10291506 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Cai Ling L DeBerardinis Ralph J RJ Xiao Guanghua G Minna John D JD Xie Yang Y
iScience 20230528 6
Lineage plasticity, especially transdifferentiation between neural/neuroendocrine (NE) and non-NE lineage, has been observed in multiple cancer types and linked to increased tumor aggressiveness. However, existing NE/non-NE subtype classifications in various cancer types were established through ad hoc approaches in different studies, making it difficult to align findings across cancer types and extend investigations to new datasets. To address this issue, we developed a generalized strategy to ...[more]