Dissecting molecular, pathological, and clinical features associated with tumor neural/neuroendocrine heterogeneity.

ABSTRACT: Lineage plasticity, especially transdifferentiation between neural/neuroendocrine (NE) and non-NE lineage, has been observed in multiple cancer types and linked to increased tumor aggressiveness. However, existing NE/non-NE subtype classifications in various cancer types were established through ad hoc approaches in different studies, making it difficult to align findings across cancer types and extend investigations to new datasets. To address this issue, we developed a generalized strategy to generate quantitative NE scores and a web application to facilitate its implementation. We applied this method to nine datasets covering seven cancer types, including two neural cancers, two neuroendocrine cancers, and three non-NE cancers. Our analysis revealed significant NE inter-tumoral heteroge

SUBMITTER: Cai L 

PROVIDER: S-EPMC10291506 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature