Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy.

ABSTRACT: Endogenic tumor chemodynamic therapy (CDT) is emerging as a tumor-therapeutic strategy featuring in situ treatments with high efficiency and specificity based on the Fenton reaction principle. Considering the limitation of monotherapy and relatively insufficient intracellular level of endogenous hydrogen peroxide (H₂O₂) in tumor tissues, a mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites is successfully fabricated to fulfill chemotherapy-augmented sequential chemoreactive tumor therapy. The bioactive cisplatin elevates the level of endogenous H₂O₂ through the activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-related cascaded reactions, and the GA-Fe(II) nanoc

SUBMITTER: Huang H 

PROVIDER: S-EPMC10291566 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature