SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology.

ABSTRACT: Perturbations to the in utero environment can dramatically change the trajectory of offspring neurodevelopment. Insults commonly encountered in modern human life such as infection, toxins, high-fat diet, prescription medications, and others are increasingly linked to behavioral alterations in prenatally-exposed offspring. While appreciation is expanding for the potential consequence that these triggers can have on embryo development, there is a paucity of information concerning how the crucial maternal-fetal interface (MFI) responds to these various insults and how it may relate to changes in offspring neurodevelopment. Here, we found that the MFI responds both to an inflammatory state and altered serotonergic tone in pregnant mice. Maternal immune activation (MIA) triggered an acute infla

SUBMITTER: Zengeler KE 

PROVIDER: S-EPMC10291741 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature