Identification and characterization of transcribed enhancers during cerebellar development through enhancer RNA analysis.

ABSTRACT:

Background

The development of the brain requires precise coordination of molecular processes across many cell-types. Underpinning these events are gene expression programs which require intricate regulation by non-coding regulatory sequences known as enhancers. In the context of the developing brain, transcribed enhancers (TEs) regulate temporally-specific expression of genes critical for cell identity and differentiation. Transcription of non-coding RNAs at active enhancer sequences, known as enhancer RNAs (eRNAs), is tightly associated with enhancer activity and has been correlated with target gene expression. TEs have been characterized in a multitude of developing tissues, however their regulatory role has yet to be described in the context of embryonic and early postnatal brai

SUBMITTER: Ramirez M 

PROVIDER: S-EPMC10291752 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature