The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration.

ABSTRACT:

Background

Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs). Notwithstanding of substantial progress in possible molecular mechanisms underlying myelination, there is no therapeutics that prevent demyelination in NDs. Therefore, it is crucial to seek for potential intervention targets. Here, we focused on the transcriptional factor, signal transducer and activator of transcription 1 (Stat1), to explore its effects on myelination and its potential as a drug target.

Methods

By analyzing the transcriptome data obtained from Schwann cells (SCs) at different stages of myelination, it was found that Stat1 might be involved in myelination. To test this, we

SUBMITTER: Xu J 

PROVIDER: S-EPMC10291779 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature