The claim of primacy of human gut Bacteroides ovatus in dietary cellobiose degradation.

ABSTRACT: A demonstration of cellulose degrading bacterium from human gut changed our view that human cannot degrade the cellulose. However, investigation of cellulose degradation by human gut microbiota on molecular level has not been completed so far. We showed here, using cellobiose as a model that promoted the growth of human gut key members, such as Bacteroides ovatus (BO), to clarify the molecular mechanism. Our results showed that a new polysaccharide utilization locus (PUL) from BO was involved in the cellobiose capturing and degradation. Further, two new cellulases BACOVA_02626^GH5 and BACOVA_02630^GH5 on the cell surface performed the degradation of cellobiose into glucose were determined. The predicted structures of BACOVA_02626^GH5 and BACOVA_02630

SUBMITTER: Li M 

PROVIDER: S-EPMC10291918 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature