Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC10291942 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Wang Shu S Sayour Elias E Lee Ji-Hyun JH
Journal of applied statistics 20220803 9
Combinational therapy that combines two or more therapeutic agents is very common in cancer treatment. Currently, many clinical trials aim to assess feasibility, safety and activity of combinational therapeutics to achieve synergistic response. Dose-finding for combinational agents is considerably more complex than single agent, because only partial order of dose combinations' toxicity is known. Prototypical phase I designs may not adequately capture this complexity thus limiting identification ...[more]