Ontology highlight
ABSTRACT:
SUBMITTER: Dudka D
PROVIDER: S-EPMC10292211 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Dudka Damian D Akins R Brian RB Lampson Michael A MA
The Journal of cell biology 20230626 9
Cell biologists typically focus on conserved regions of a protein, overlooking innovations that can shape its function over evolutionary time. Computational analyses can reveal potential innovations by detecting statistical signatures of positive selection that lead to rapid accumulation of beneficial mutations. However, these approaches are not easily accessible to non-specialists, limiting their use in cell biology. Here, we present an automated computational pipeline FREEDA that provides a si ...[more]